Anemia

Disease Iron TIBC/Transferrin UIBC % Transferrin Saturation Ferritin Iron Deficiency Low High High Low Low Hemochromatosis High Low Low High High Chronic Illness Low Low Low/Normal Low Normal/High Hemolytic Anemia High Normal/Low Low/Normal High High Sideroblastic Anemia Normal/High Normal/Low Low/Normal High High Iron Poisoning High Normal Low High Normal Advertisements

Anemia

Causes of anemia Decreased production of RBCs (Fe deficiency, kidney disease, cancer, EPO deficiency) Blood loss (GI bleed, surgery) Excessive destruction of RBCs (sickle cell anemia, autoimmune hemolytic anemia) Normocytic anemia:  caused by chronic disease or blood loss Microcytic anemia:  caused by Fe deficiency Macrocytic anemia:  caused by either Folic acid or B12 deficiency Normochromic … Continue reading

Sickle Cell Anemia

Etiology of sickle disease and its effects on organs Sickle cell disease is an autosomal recessive disease (need to be homozygous recessive) that results from a single AA substitution resulting in hemoglobin S NOT SEX LINKED RBCs that contain sickle cell hemoglobin only lives for 20 days (rather than 120 for normal RBCs), they eventually … Continue reading