Inpatient Anticoagulation

Direct and indirect anticoagulants utilized in the inpatient setting Indirect anticoagulantsĀ  (heparin, LMWHs, & fondaparinux–factor Xa inhibitor): Activity is mediated by plasma cofactors Activate antithrombin (AT–endogenous inhibitor of various clotting factors) Direct anticoagulants (bivalirudin, hirudins, & argatroban) DON’T require plasma cofactors for activity Directly target thrombin Pharmacodynamic and pharmacokinetic properties of each agent UFH (unfractionated … Continue reading