Abuse, Addiction and Dependence

Addiction:  a primary, chronic, neurobiological disease with genetic, psychosocial and environmental factors with influence its development and manifestations.  It is characterized by behaviors that include decreased control over drug use, complusive use, continued use despite harm and/or craving.

Physical Dependence:  a state of adaptation that is manifested by a drug-class-specific withdrawal syndrome that can be produced by abrupt cessation, rapid dose reduction, decreasing blood level of the drug, and/or administration of an antagonist.

Tolerance:  a state of adaptation in which exposure to a drug induces changes that result in a diminution of one or more of the drug’s effects over time.

Pseudo Addiction:  The development of problematic drug related behaviors that are driven by desperation surrounding unrelieved pain.

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