Hypervolemic Hyponatremia

Hypotonic hyponatremia with increased ECF volume  (hypervolemic hyponatremia)

  • Excess of both total body Na & water
    • Excess of TBW is greater than the excess of Na
  • Results in chronic fluid overload
  • Causes: CHF, hepatic cirrhosis, nephrotic syndrome, renal failure (both acute & chronic)
  • Trxt: hypertonic NaCl/fluid restriction, loop diuretic + treat the underlying disorder
  • Drug trxt:  conivaptan or tolvaptan (arginine vasopressin (AVP) receptor antagonist)
    • Avoid 3A4 inhibitors

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: