Tumor Lysis Syndrome

Tumor lysis syndrome

Electrolyte abnormality

Complications

Treatment/Management

Hyperkalemia Arrhythmias, hypotension, N/V Aggressive hydration, calcium gluconate, dextrose, sodium polystyrene sulfonate
Hyperphosphatemia Anuria, oliguria, edema, ARF, N/V, diarrhea, seizures Aluminum hydroxide, sevelamer carbonate
Hypocalcemia Prolonged QT, intestinal cramping, weakness, seizures Possibly calcium gluconate but resolves with normalization of Phosphate
Hyperuricemia Renal failure, CHF Hydration, dialysis

Allopurinol and rasburicase

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